1. To greatly irritate or annoy someone, especially to the point of affecting their nerves. (A less common variant of "set someone's teeth on edge.") Nothing puts my teeth on edge like seeing these damn cyclists run every red light in town! I don't know what it is about Terry, but there's something about his demeanor that just puts my teeth on edge!

2. To cause someone to be upset, nervous, or uncomfortable. Please don't tell me about your surgery, it puts my teeth on edge hearing about blood and gore.