noun the synthetic opiate oxycodone used recreationally. When dissolved in water and injected, or crushed and inhaled, it has a similar effect to heroin. The drug's popularity in the rural Appalachian Mountains region led to the 'hillbilly' reference. It came to the forefront of the American national conscious in late 2003 when radio entertainer Rush Limbaugh was reported to be addicted to OxyContin™ US, 2001